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KMID : 0811720130170050469
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Korean Journal of Physiology & Pharmacology
2013 Volume.17 No. 5 p.469 ~ p.477
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Effect of ECQ on Iodoacetamide-Induced Chronic Gastritis in Rats
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Lee Se-Eun
Song Hyun-Ju
Park Sun-Young
Nam Yoon-Jin
Min Chang-Ho
Lee Do-Yeon
Jeong Jun-Yeong
Ha Hyun-Su
Kim Hyun-Jung
Whang Wan Kyunn
Jeong Ji-Hoon
Kim In-Kyeom
Kim Hak-Rim
Min Young-Sil
Sohn Uy-Dong
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Abstract
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This study investigated effect of extract containing quercetin-3-O-?-D-glucuronopyranoside from Rumex Aquaticus Herba (ECQ) against chronic gastritis in rats. To produce chronic gastritis, the animals received a daily intra-gastric administration of 0.1 ml of 0.15% iodoacetamide (IA) solution for 7 days. Daily exposure of the gastric mucosa to IA induced both gastric lesions and significant reductions of body weight and food and water intake. These reductions recovered with treatment with ECQ for 7 days. ECQ significantly inhibited the elevation of the malondialdehyde levels and myeloperoxidase activity, which were used as indices of lipid peroxidation and neutrophil infiltration. ECQ recovered the level of glutathione, activity of superoxide dismutase (SOD), and expression of SOD-2. The increased levels of total NO concentration and iNOS expression in the IA-induced chronic gastritis were significantly reduced by treatment with ECQ. These results suggest that the ECQ has a therapeutic effect on chronic gastritis in rats by inhibitory actions on neutrophil infiltration, lipid peroxidation and various steps of reactive oxygen species (ROS) generation.
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KEYWORD
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Chronic gastritis, Iodoacetamide, QGC, Reactive oxygen species, Superoxide dismutase
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